Scripts underlying DNAm findings in the GOTO study
DNAmArray
Script 1: Splitting Data
Script 2: Saving sData for MethylAid
Script 3: MethylAid and PCA
Script 4: Checking genotypes with omicsPrint
Script 5: Genotype checking for LLS
Script 6: Genotype checking for GOTO
Script 7: Sample corrections
Script 8: Functional normalization
Script 9: Probe-level QC
Script 10: Descriptive tables
Script 11: Non-response analysis
Skeletal Muscle
Script 12: Base model
Script 13: Clustering single nuclei data
Script 14: Predicting nuclei-type proportions
Script 15: Estimating changes in nuclei-types
Script 16: Adjusted model
Script 17: Volcano plot
Script 18: DMRs and Homer
Script 19: Chromatin state enrichment
Script 20: Differentially expressed genes
Script 21: eQTM analysis
Script 22: Trait DNAm associations
Script 23: Output dotplot figures
Subcutaneous Adipose
Script 24: Base model
Script 25: Estimating changes in cell-types
Script 26: Volcano plot
Script 27: DMRs and Homer
Script 28: Chromatin state enrichment
Script 29: Differentially expressed genes
Script 30: eQTM analysis
Script 31: Trait DNAm associations
Script 32: Output dotplot figures
Fasted Blood
Script 33: Base model
Script 34: Predicting cell-type proportions
Script 35: Estimating changes in cell-types
Script 36: Volcano plot
Script 37: DMRs and Homer
Script 38: Chromatin state enrichment
Script 39: Differentially expressed genes
Script 40: eQTM analysis
Script 41: Trait DNAm associations
Epigenetic Clocks
Script 42: Prediction
Script 43: dnaMethyAge
Script 44: Bernabeu bAge prediction
Script 45: Predicting MEAT from muscle DNAm
Script 46: Plots and trait associations
Work in progress - add link to MedRXiv